ISO 19238:2014 辐射防护 用细胞遗传学实行生物剂量测定的工作实验室的性能准则

标准编号：ISO 19238:2014

中文名称：辐射防护 用细胞遗传学实行生物剂量测定的工作实验室的性能准则

英文名称：Radiological protection — Performance criteria for service laboratories performing biological dosimetry by cytogenetics

发布日期：2014-02

标准范围

ISO 19238:2014提供了细胞遗传学服务实验室的质量保证和质量控制、性能评估和生物剂量学认证标准。ISO 19238:2014地址a） 为客户和服务实验室保密的个人信息，b） 实验室安全要求，c） 校准源和校准剂量范围有助于建立参考剂量效应曲线，该曲线有助于根据染色体畸变频率和最小可分辨剂量估算剂量，d） 用于生物剂量测定的不稳定染色体畸变评分程序，e） 将测量的畸变频率转换为吸收剂量估计值的标准，f） 报告结果，g） 质量保证和质量控制，h） 资料性附录，包括客户样本说明、样本问卷、报告样本、通过最大似然法拟合低剂量-反应曲线并计算剂量估计误差、疑似低剂量暴露病例的优势比法，以及记录畸变的样本数据表。

ISO 19238:2014 provides criteria for quality assurance and quality control, evaluation of the performance, and the accreditation of biological dosimetry by cytogenetic service laboratories.ISO 19238:2014 addressesa) the confidentiality of personal information, for the customer and the service laboratory,b) the laboratory safety requirements,c) the calibration sources and calibration dose ranges useful for establishing the reference dose-effect curves that contribute to the dose estimation from chromosome aberration frequency and the minimum resolvable doses,d) the scoring procedure for unstable chromosome aberrations used for biological dosimetry,e) the criteria for converting a measured aberration frequency into an estimate of absorbed dose,f) the reporting of results,g) the quality assurance and quality control,h) informative annexes containing sample instructions for customer, sample questionnaire, sample of report, fitting of the low dose-response curve by the method of maximum likelihood and calculating the error of dose estimate, odds ratio method for cases of suspected exposure to a low dose, and sample data sheet for recording aberrations.

标准预览图