ISO/TS 23973:2020 临界条件下的液相色谱法（LCCC） 聚乙烯氧化物的化学不均匀性

标准编号：ISO/TS 23973:2020

中文名称：临界条件下的液相色谱法（LCCC） 聚乙烯氧化物的化学不均匀性

英文名称：Liquid chromatography at critical conditions (LCCC) — Chemical heterogeneity of polyethylene oxides

发布日期：2020-08

标准范围

本文件建立了一种有效的方法，用于分离化学不均聚氧化乙烯（PEO）混合物，并测定整个样品中化学不均物种的数量和含量。本文件中介绍的方法作为技术指南，使实验室能够在经过验证的系统上学习“临界色谱法”的原理。由于聚合物/流动相/固定相之间的相互作用的多样性以及因此可用的分离系统的数量，本文件中所述的方法及其规定的系统参数不适用于其他聚合物类别。实验室间测试的评估表明，许多误差源通常与液相色谱技术有关。附件A中描述了可能的误差源。实验室间试验的评估详情见附录B。附录C中给出了参与者的简历（摘录）。附录D中给出了试验混合物长期稳定性的调查结果。

This document establishes a valid method for separation of chemically heterogeneous polyethylene oxide (PEO) mixtures and for the determination the number and content of the chemically heterogeneous species in the overall sample.The method presented in this document serves as a technical guideline and enables laboratories to learn the principle of "critical chromatography" on a validated system.This method presented in this document with its stated system parameters is not applicable for other polymer classes, due to the diversity of the interactions between the polymer/mobile phase/stationary phase and the number of separation systems that are therefore available.The evaluation of the interlaboratory testing has shown that many error sources relate to the technique of liquid chromatography in general. Possible error sources are described in Annex A.Details on the evaluation of the interlaboratory testing are given in Annex B.Elugrams of the participants (excerpts) are given in Annex C.Investigations of the long-term stability of the test mixture are given in Annex D.

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