ISO 23196:2022 水质 生物当量（BEQ）浓度的计算

标准编号：ISO 23196:2022

中文名称：水质 生物当量（BEQ）浓度的计算

英文名称：Water quality — Calculation of biological equivalence (BEQ) concentrations

发布日期：2022-02

标准范围

本文件规定了体外生物测定结果的生物等效性（BEQ）浓度的推导，其基于对生物过程（如酶诱导或细胞生长）的测量效果。在证明其适用性后，这里描述的概念可用于任何生物分析。为了得出BEQ浓度，样品对生物过程的影响（即样品的活性）用参考化合物的浓度表示，该浓度会对生物过程产生同等影响。本文件中使用的术语“样品”涉及环境样品以及生物测定中用作测试项目的定义混合物和纯化合物。环境水样、包括自来水在内的环境水样提取物、纯化学品溶液或化学品混合物的BEQ浓度可以推导出来。

This document specifies the derivation of biological equivalence (BEQ) concentrations for results of in vitro bioassays which are based on measuring effects on a biological process such as enzyme induction or cellular growth. The concept described here can be used for any biological assay after the proof of its applicability.To derive BEQ concentrations, the effect on a biological process caused by a sample – i.e. the activity of the sample – is expressed in terms of a concentration of a reference compound which results in an equivalent effect on the process. The term "sample" used in this document addresses environmental samples as well as defined mixtures and pure compounds used as test item in a bioassay. BEQ concentrations can be derived for environmental water samples, extracts of environmental water samples including tap water or solutions of pure chemicals or mixtures of chemicals.

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